Do Supplements Really Work for Depression?

By Jessica Migala, Oct 21, 2025

Clinical depression—the most severe form of depression—is complicated, and influenced by a variety of factors including individual brain chemistry, genetics, a history of trauma, and stress. Treatment of the condition, too, is complex, needing to address the biological, genetic, environmental, and psychosocial factors at play, which differ from person-to-person. “For depression treatment, I strongly believe in a multimodal approach, as evidenced by research,” says psychiatrist Alex Dimitriu, M.D., the founder of Menlo Park Psychiatry & Sleep Medicine in California. “In my practice, we help people with daily life habits likesleep, work, play, and exercise, we add therapy to improve understanding of the patient and their relationships, and we use medication when needed.”

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