Antidepressants are ineffective for treating chronic pain, review finds

By Annie Lennon, May 16, 2023

To understand why duloxetine and milnacipran — and not other antidepressants — may reduce chronic pain in the short term, Medical News Today spoke with Dr. Alex Dimitriu, double board-certified in psychiatry and sleep medicine, and founder of Menlo Park Psychiatry & Sleep Medicine, not involved in the study. He told us: “Both duloxetine and milnacipran offer some advantage to pain. The reason is that these medications work on norepinephrine, implicated in pain perception, as well as serotonin, implicated in depression.”

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