Restless leg syndrome may increase Parkinson’s disease risk, study finds

By Jessica Freeborn, Dec 11, 2025

Alex Dimitriu, MD, double board-certified in Psychiatry and Sleep Medicine and founder of Menlo Park Psychiatry & Sleep Medicine, likewise not involved in the study, told us: “I am not sure I agree with the authors that dopamine may not be the single agent responsible for the [restless leg syndrome]- Parkinson’s relationship. In my professional work, I have seen dopamine-related conditions go hand in hand with others. Specifically, people who have akathisia (restlessness) with dopamine blocking meds, also tend to have [restless leg syndrome]. And patients with [restless leg syndrome] are more likely to develop tremor and akathisia (all symptoms of lower dopamine).”

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