By Julia Rachel Malacoff, March 04, 2020
Another potential (and ironic) side effect of some antihistamine-containing OTC sleep aids is less-than-great sleep. “There is some concern that diphenhydramine may also negatively impact sleep by reducing REM sleep (or dream sleep),” says Dr. Dimitriu. Lack of REM sleep can affect your memory, mood, cognitive performance, and even cell regeneration, so this can be pretty problematic.
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