Can I Take St. John’s Wort With Lexapro?
By Macy Alcido, Jan 29, 2025
The risk of serotonin syndrome intensifies when drugs designed to boost serotonin production are taken together, such as Lexapro and St. John’s wort, says Alex Dimitriu, M.D., a dual board-certified specialist in Psychiatry and Sleep Medicine, and founder of Menlo Park Psychiatry & Sleep Medicine. St. John’s wort works like a natural SSRI, increasing serotonin levels, notes Dr. Dimitriu. When the herbal supplement is taken alongside Lexapro, individuals might have too much serotonin in their systems and experience serotonin syndrome, he explains.
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